Product Information
HOWARU® B420™
- 90 scientific publications
- 30+ clinical trial publications
Health Benefits:
Metabolic Health
The primary health attributes of HOWARU® Bifidobacterium lactis B420™ are weight management and metabolic health, which may be related to its ability to support intestinal barrier integrity.¹⁻³ In addition, Akkermansia muciniphila, a bacterial species linked to lean healthy body weight, was increased in abundance in the intestine upon B420™ supplementation.⁴
B420™, also known as HOWARU® Shape, has demonstrated promise in both human clinical trials and animal studies in supporting weight management and inducing a better metabolic state.⁵⁻⁷
B. lactis B420™ has been documented in more than 90 scientific publications, including more than 30 clinical trial publications. It has been demonstrated in clinical trials to survive intestinal passage, and in vitro studies have shown excellent adhesion to human colonic mucus.⁸⁻¹⁰
Health Benefit Area | Supporting Daily Dose | Study Reference |
|---|---|---|
Metabolic Health | 10B CFU B420™ | • Stenman LK, et al. EBioMedicine. 2016. Nov;13:190–200. • Hibberd A, et al. Beneficial Microbes. 2019. 10(2):121-135(15). |
References: 1. Lindfors K et al.; Clin Exp Immunol. 2008; 2. Putaala H at al.; Res Microbiol. 2008; 3. Mokkala K et al.; Nutr Res. 2016; 4. Hibberd AA et al.;Beneficial Microbes. 2018; 5. Stenman LK et al.;EBioMedicine. 2016; 6. Stenman LK et al.;Diabetology & Metabolic Syndrome. 2015; 7. Stenman LK et al.;Beneficial Microbes. 2014; 8. Klein A et al.;Eur J Clin Nutr. 2008; 9. Kok RG et al.; Appl Environ Microbiol. 1996; 10. Collado MC et al.;Lett Appl Microbiol. 2007.
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