Product Information

HOWARU® Bl-04®​

  • ~66 preclinical studies​
  • ~49 clinical publications​

Health Benefits:

Beauty

Digestive Health

Immune Health

HOWARU® Bifidobacterium lactis Bl-04®, a human isolate long considered safe and suitable for human consumption, is well known for its excellent stability. Bl-04® has been thriving in a variety of foods and supplements for decades, and it has also been shown to survive passage through the human intestine.¹,² Bl-04® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for immune health.³,⁴​

LEARN MORE ABOUT OUR Bl-04® BLENDS ​

HOWARU® GI Complete​

HOWARU® GI Complete is a unique probiotic blend for gastro-intestinal wellbeing.​

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HOWARU® Protect Adult​

HOWARU® Protect Adult provides immune defense for overall health and wellness in adults.​

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HOWARU® Restore​

HOWARU® Restore promotes good digestive health during episodes of gut stress.​

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Bl-04® CLINICAL STUDIES & PUBLICATIONS​

With more than 49 clinical trial publications, Bl-04® has also been studied in combination with other strains, not only in HOWARU® Protect Adult for immune support, but also as part of the HOWARU® Restore blend for digestive health.⁵

HOWARU® Bl-04®​

Health Benefit Area​

Supporting Daily Dose​

Study Reference​

Digestive Health​

17B (equal parts) Bl-04®, NCFM®, Bi-07®, Lpc-37®​

Ouwehand AC, et al. Vaccine. 2014;32(4):458-463.​

Digestive Health​

10B CFU Total Bi-07®, Bl-04®, NCFM®, Lpc-37®​

van Zanten G, et al. Microorganisms. 2024; 12(4),796. ​

Immune Health​

2B CFU Bl-04®​

West NP, et al. Clin Nutr. 2014;33(4):581-587.​

Turner RB, et al. Benef Microbes. 2017;8(2):207-215.

Immune Health​

1B CFU NCFM®, 3B CFU Bl-04®, 1 g FOS ​

Bergmann K, et al. World Allergy Organ J. 2021;14(1):100494. ​

Beauty​

1.75B CFU Bl-04®​

Huuskonen L, et al. Dermato. 2022;2(2):30-52. ​

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References:1. Bartosch S et al.; Clin Infect Dis. 2005; 2. Ouwehand AC et al.; World J Gastroenterology. 2009; 3. Turner R et al.;Beneficial Microbes. 2017; 4. West NP et al.; Clin Nutr. 2014; 5. Ouwehand AC et al.;Vaccine. 2014.​

How can we help?​

We’d love to talk to you about how our microbiome and bioscience expertise can help you develop, manufacture and deliver solutions that enable people at all life stages to live healthier and happier lives.

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